H4K20me3, H3K4me2 and H3K9me2 mediate the effect of ER on prognosis in breast cancer.

AI-algorithm training and validation for identification of endometrial CD138+ cells in infertility-associated conditions; polycystic ovary syndrome (PCOS) and recurrent implantation failure (RIF).

Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression.

PAX8 expression in cancerous and non-neoplastic tissue: a tissue microarray study on more than 17,000 tumors from 149 different tumor entities.

Fig. 1 OXA upregulates YTHDF2 in peritumoral hepatocytes and YTHDF2 upregulation is associated with improved survival outcomes. 

d, Immunohistological staining of YTHDF2 in peritumoral tissues from treatment naive HCC patients and HCC patients treated with HAIC. e, Histochemistry score (H-SCORE) value of YTHDF2 in peritumoral tissues from treatment naive HCC patients and HCC patients treated with HAIC (n=20). f, Immunohistological staining of YTHDF2 in human HCC tissue microarrays, and IOD value of YTHDF2 in paired tumor and peritumoral tissues of treatment-naïve patients (n=103).

YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment.

Role of Fyn expression in predicting the sensitivity to platinum‑based chemotherapy in patients with ovarian serous carcinoma.

Dexamethasone acetate loaded poly(ε-caprolactone) nanofibers for rat corneal chemical burn treatment.

Fig. 2 FTO is the key factor leading to distinct m6 A levels among different growth hormone-secreting pituitary neuroendocrine tumor subtypes. 

f-g. Immunohistochemical staining for FTO in DGGH and SGGH tissue samples.

FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors.

Figure 1: PEA tissue and serum of CTEPH patients showed elevated PKM2 expression. (A) Hematoxylin and eosin staining of PEA tissue showed thickened vessel wall with narrowed lumen, thrombus organization and neovascularization. The red square and the line in the picture showed a zoomed in local area and displayed at below. Scale bar: 50 μm, n = 3–6. (B) Expression and localization of PKM2 and PKM1 in PEA tissues and control vessels are shown by immunohistochemistry. Expression of PKM2 was increased significantly in PEA tissue compared to the control group, while expression of PKM1 showed no significant changes. Scale bar: 50 μm, n = 3.

Inhibition of heterogeneous nuclear ribonucleoproteins A1 and oxidative stress reduces glycolysis via pyruvate kinase M2 in chronic thromboembolic pulmonary hypertension.

Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma.