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> 제품정보 > 시약 > 해외 공식 대리점 > [1422-010] Human Activin A (also known as inhibin beta A chain), accession # P08476, Gly311-Ser426
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[1422-010] Human Activin A (also known as inhibin beta A chain), accession # P08476, Gly311-Ser426

제품코드 : 1422-010

제품정보 : CellGenix® Recombinant Human Activin A reliably promotes definitive endoderm differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). It in addition maintains the undifferentiated state of ESCs and iPSCs. CellGenix® rh Ac

  • Produced in our dedicated animal-free facility
  • Compliant to USP <1043> and Ph. Eur. General Chapter 5.2.12 (GMP)

제품문의

  • 전화번호
    2292-8870

제품상세

General Information

Activin A belongs to the transforming growth factor beta (TGF-β) superfamily. It regulates a variety of biological functions, including cell proliferation, differentiation, apoptosis and wound repair.

Activin A is used in the cell and gene therapy space to promote differentiation of ESCs and iPSCs into definitive endoderm, and for the maintenance and self-renewal of pluripotent stem cells (PSCs).


Technical Details

Source
Expressed in E. coli
Description

Human Activin A (also known as inhibin beta A chain), accession # P08476, Gly311-Ser426

Formulation

Lyophilized from a 0.2 µm-filtered solution containing 20 mM glycine, 150 mM sodium chloride and 3% mannitol, pH 9.5

Both product grades are produced under the same conditions in a GMP facility, ensuring an equal product quality and performance. We offer a more comprehensive QC testing including tighter specifications and documentation for our GMP products: Preclinical vs GMP.

 
 PreclinicalGMP
Molecular weight26.2 kDa per homodimer26.2 kDa per homodimer
Purity≥ 95% as determined by SDS-PAGE≥ 97% as determined by SDS-PAGE
Activity≥ 0.5 x 103 IU/mg, calibrated against NIBSC #91/626
Measured by inhibition of proliferation of MPC-11 cells
0.6 – 2.5 x 103 IU/mg, calibrated against NIBSC #91/626
Measured by inhibition of proliferation of MPC-11 cells

Batch specific activity on CoA

Endotoxin level< 1000 EU/mg≤ 50 EU/mg
Intended useIntended for preclinical ex vivo use. Not intended for therapeutic use.Intended for clinical ex vivo use. Not intended for human in vivo application.

Handling Instructions

Reconstitution

Recommended in sterile water to a final concentration of 250 µg/ml for 50 µg vials.

Shipment

Ambient temperature. Please refer to our Technote Shipment of CellGenix® Preclinical and GMP Cytokines at Ambient Temperatures.

Expiry

≥ 6 months from date of shipping. Please refer to Certificate of Analysis for the exact expiry date.

Storage & Stability

Store lyophilized cytokine at -20°C to -80°C.

Store a 100 µg/ml reconstituted cytokine solution:

• 4 weeks at 2°C to 8°C under sterile conditions after reconstitution. Store in the original container. 

• 4 months at -20°C to -80°C under sterile conditions after reconstitution. Store in 60 µl aliquots in polypropylene cryogenic vials.

Avoid repeated freeze/thaw cycles.