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> 제품정보 > 시약 > 해외 공식 대리점 > [1419-050] Human IL-21, accession # Q9HBE4, Gln25-Ser155
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[1419-050] Human IL-21, accession # Q9HBE4, Gln25-Ser155

제품코드 : 1419-050

제품정보 : CellGenix® Recombinant Human IL-21 reliably promotes the proliferation of T cells and natural killer cells (NK cells) and enhances their cytotoxic function. CellGenix® rh IL-21 is produced in our dedicated animal-free GMP facility ensuring maximum safety

  • Produced in our dedicated animal-free facility
  • Compliant to USP Chapter <1043> and Ph. Eur. General Chapter 5.2.12 (GMP)
  • FDA Drug Master File available (GMP)

제품문의

  • 전화번호
    2292-8870

제품상세

General Information

Interleukin-21 (IL-21) is a cytokine that plays an important role in humoral and adaptive immune responses. It stimulates the proliferation of NK cells and multiple T cell subsets, especially cytotoxic T cells. It is produced by activated CD4+ T helper cells and NK T cells.

IL-21 is used in the cell and gene therapy space for the ex vivo expansion of T cells, including CAR T cells and TCR T cells and NK cells.


Technical Details

Source
Expressed in E. coli
Description

Human IL-21, accession # Q9HBE4, Gln25-Ser155

Formulation

Lyophilized from 200 µl of a 0.2 µm-filtered solution containing 15 mM sodium acetate and 45 mM sodium chloride, pH 5.5

Both product grades are produced under the same conditions in a GMP facility, ensuring an equal product quality and performance. We offer a more comprehensive QC testing including tighter specifications and documentation for our GMP products: Preclinical vs GMP.

 PreclinicalGMP
Molecular weight15.4 kDa15.4 kDa
Purity≥ 95% as determined by SDS-PAGE≥ 97% as determined by SDS-PAGE
Activity≥ 0.5 x 106 U/mg, calibrated against internal standard “IL-21 RS1” Measured in a cell proliferation assay using an IL-21-dependent cell line, mouse hybridoma B-cells (B9)0.5 – 1.6 x 106 U/mg, calibrated against internal standard “IL-21 RS1” Measured in a cell proliferation assay using an IL-21-dependent cell line, mouse hybridoma B-cells (B9)

Batch specific activity on CoA

Endotoxin level< 25 EU/mg≤ 25 EU/mg
Intended useIntended for preclinical ex vivo use. Not intended for therapeutic use.Intended for clinical ex vivo use. Not intended for human in vivo application.

Handling Instructions

Reconstitution

Recommended in sterile water to a final concentration of 250 µg/ml.

Shipment

Ambient temperature. Please refer to our Technote Shipment of CellGenix® Preclinical and GMP Cytokines at Ambient Temperatures.

Expiry

≥ 6 months from date of shipping. Please refer to Certificate of Analysis for the exact expiry date.

Storage & Stability

Store lyophilized cytokine at -20°C to -80°C.

Store a 100 µg/ml reconstituted cytokine solution:

• 4 weeks at 2°C to 8°C under sterile conditions after reconstitution. Store in the original container. 

• 4 months at -20°C to -80°C under sterile conditions after reconstitution. Store in 60 µl aliquots in polypropylene cryogenic vials.

Avoid repeated freeze/thaw cycles.