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홈 > 제품정보 > 시약 > 해외 공식 대리점 > [1413-050] Human IL-15, accession # P40933, Asn49-Ser162
[1413-050] Human IL-15, accession # P40933, Asn49-Ser162
제품코드 : 1413-050
제품정보 : CellGenix® Recombinant Human IL-15 reliably promotes the proliferation of T cells. It also stimulates the proliferation of natural killer cells (NK cells) and promotes the generation of cytokine-induced killer cells (CIK cells). CellGenix® rh IL-15 is pro
- Produced in our dedicated animal-free facility
- Compliant to USP Chapter <1043> and Ph. Eur. General Chapter 5.2.12 (GMP)
- FDA Drug Master File available (GMP)
제품문의
-
- 전화번호
- 2292-8870
- 이메일
- dreamcell@dreamcell.co.kr
제품상세
General Information
Interleukin-15 (IL-15) is a cytokine that plays an important role in humoral and adaptive immune responses. It induces or enhances the differentiation, maintenance, or activation of NK cells and multiple T cell subsets. IL-15 is produced by a large number of cell types, including monocytes, macrophages, dendritic cells, keratinocytes, fibroblasts and nerve cells.
IL-15 is used in the cell and gene therapy space for the ex vivo expansion of various T cells (CAR T cells, TCR T cells and TILs) as well as NK cells and the generation of CIK cells.
Technical Details
Source
Expressed in E. coli
Description
Human IL-15, accession # P40933, Asn49-Ser162
Formulation
Lyophilized from 200 µl of a 0.2 µm-filtered solution containing 20 mM potassium phosphate, 300 mM sodium chloride and 0.1% polysorbate 20, pH 7.5
Both product grades are produced under the same conditions in a GMP facility, ensuring an equal product quality and performance. We offer a more comprehensive QC testing including tighter specifications and documentation for our GMP products: Preclinical vs GMP.
| Preclinical | GMP | |
| Molecular weight | 13.7 kDa | 13.7 kDa |
| Purity | ≥ 95% as determined by SDS-PAGE | ≥ 97% as determined by SDS-PAGE |
| Activity | ≥ 8 x 106 IU/mg, calibrated against NIBSC #95/554 Measured in a cell proliferation assay using an IL-15-dependent cell line, CTLL-2 | 8 – 30 x 106 IU/mg, calibrated against NIBSC #95/554 Measured in a cell proliferation assay using an IL-15-dependent cell line, CTLL-2 Batch specific activity on CoA |
| Endotoxin level | < 25 EU/mg | ≤ 25 EU/mg |
| Intended use | Intended for preclinical ex vivo use. Not intended for therapeutic use. | Intended for clinical ex vivo use. Not intended for human in vivo application. |
Handling Instructions
Reconstitution
Recommended in sterile water to a final concentration of 250 µg/ml.
Shipment
Ambient temperature. Please refer to our Technote Shipment of CellGenix® preclinical and GMP cytokines at ambient temperatures.
Expiry
≥ 6 months from date of shipping. Please refer to Certificate of Analysis for the exact expiry date.
Storage & Stability
Store lyophilized cytokine at -20°C to -80°C.
Store a 250 µg/ml reconstituted cytokine solution:
• 4 weeks at 2°C to 8°C under sterile conditions after reconstitution. Store in the original container.
• 4 months at -20°C to -80°C under sterile conditions after reconstitution. Store in 60 µl aliquots in polypropylene cryogenic vials.
Avoid repeated freeze/thaw cycles.